中文
Published date:2014-07-16    Provided by:School of Science
 
Title: The Singlet Oxygen Microscope: Near IR optical imaging and nonlinear optical control   of events in single mammalian cells
Guest SpeakerProfessor Peter R. Ogilby, Aarhus Universit
Time2014-5-30, 9:00-11:00
LocationMeeting Room 7215, School of Science
Content &Introduction 
Singlet oxygen, the lowest excited electronic state of molecular oxygen, has been studied for many years from a wide range of perspectives.  Among other things, singlet oxygen has a unique chemistry that results in the oxygenation of many organic Molecules.  In this way, it plays important roles in biology, particularly in mechanisms of cell signaling and cell death.
Singlet oxygen is commonly produced in a photosensitized process wherein light is absorbed by a given molecule (the so-called sensitizer) followed by energy transfer from the excited state sensitizer to ground state oxygen.  The production of singlet oxygen in this way is a natural phenomenon (i.e., we live in a world of light, oxygen, and suitable sensitizers).
We have a multi-faceted program in which the behavior of sing let oxygen is examined under conditions and in systems that have, heretofore, been inaccessible. I will briefly describe our latest work on (a) methods to optically detect and image singlet oxygen and (b) methods to selectively control the photosensitized production of singlet oxygen in single mammalian cells. 
Our results indicate that there is still much to be gained from studies of singlet oxygen.