中文
Published date:2014-03-14    Provided by:生物科学与生物工程研究院
Personal Information
 
  • Title:Professor
  • Position:Dean Assistant of School of Science and deputy director of College of Life Sciences and Bioengineering, Beijing Jiaotong University
  • Tel:+86-10-51684080 (O)
  • E-mail:jshhe@bjtu.edu.cn
  • Present Address:School of Science, Beijing Jiaotong University,No 3. Shangyuancun, Haidian District,Beijing, P.R.China, 100044
  Education
1981.09-1986.06 BS., Anhui Medical University, China
1990.09-1994.06 MS., Anhui Medical University, China
1998.09-2001.07 MD., Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China
2004.10-2005.10 Visiting scholar, University of Toronto, Canada
  Research Interest
Novel anti-RNA virus stratigeies: Mucosally delivered vaccine and potential target for drug development.
Molecular Mechanism of Ab pathology in AD: FAD caused by APP mutant in China. 
Immunotherapy for AD: The active and passive immunotherapy for AD, such as Ab42 peptide vaccine and Ab42 specific monoclonal antibody.
  Funding
1. National Major Scientific and Technological Special Project for "AIDS and Viral Hepatitis and Other Major Infectious Diseases Prevention and Control" (2013ZX10004-601), “High throughput screening platform for the biomarkers of pathogens for diagnosis and treatment by chemical genomics”. 2013-2015. Role: PI
2. National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2013ZX09103-003-011), “The development of the attenuated vaccine of respiratory syncytial virus”. 2013-2015. Role: PI
3. The National Natural Fund (30972604), The investigation on enhancing the protective role of recombinant adenovirus-based Respiratory syncytial virus vaccine. 2010-2012Role: PI
4. The National Natural Fund(30671965), Human respiratory syncytial virus vaccine based on help-dependent adenovirus vector. 2007-2009. Role: PI
5. The National Natural Fund(30371320), Protection immunity against RSV infection induced by DNA and replication-defective adenoviral recombinant encoding the attachment(G) and fusion(F) protein. 2004.1-2004.12. Role: PI
6. The National Natural Fund(30471519), Oral DNA vaccination against respiratory syncytial virus infection among infant. 2005-2007. Role: PI
7. National High Technology Research and Development Program of China (863 Program) (2006AA02A247), “Preparation, characterization and modification of amyloid-beta 42 oligomer-specific monoclonal antibody”. 2006-2010. Role: PI
  Major Publication
 1. Yuan-Hui Fu, Yue-Ying Jiao, Jinsheng He, Gui-Yun Jiang, Wei Zahng, Yao Ma, Ying Zhang, Chang-Xin Shi, Xiang-Lei Peng, Tao Hong, Yi-Fei Yan. Sublingual administration of a helper-dependent adenoviral vector expressing the codon-optimized soluble fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in mice. Antiviral Research. 2014, in press, AVR3386 (corresponding author) 
2. Yuan-hui Fu, Jin-sheng He, Wei Qiao, Yue-ying Jiao, Ying Hua, Ying Zhang, Xiang-Lei Peng, and Tao Hong. Intranasal immunization with a helper-dependent adenoviral vector expressing the codon-optimized fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in BALB/c mice. Virol J, 2013, 10:183. DOI: 10.1186/1743-422X-10-183 (corresponding author) 
3. Ying Zhang, Jin-Sheng HE, Xin WANG, Jun Wang, Fu-Xiang BAO, Si-Yuan Pang, Fan Yin, Tao Hong. Administration of Amyloid-?42 Oligomer-Specific Monoclonal Antibody Improved Memory Performance in SAMP8 Mice. J Alzheimers Dis, 2011, 23 (3): 551-561 (corresponding author)
  
4. Yuanhui Fu, Jinsheng He, Xianxian Zheng, Xiao-bo Wang, Can Xie, Chang-xin Shi, Mei Zhang, Qian Tang, Wei Wei, Jian-guo Qu and Tao Hong. Intranasal vaccination with a helper-dependent adenovirus vector enhances transgene-specific immune responses in BALB/c mice. Biochem Biophys Res Commun, 2010, 391(1): 857-861 (corresponding author
5. Fu Yuanhui, He Jinsheng, Zheng Xianxian, Wu Qiang, Zhang Mei, Wang Xiaobo, Wang Yan, Xie Can, Tang Qian, Wei Wei, Wang Min, Song Jingdong, Qu Jianguo, Zhang Ying, Wang Xin, Hong Tao. Intranasal Immunization with a Replication-Deficient Adenoviral Vector Expressing the Fusion Glycoprotein of Respiratory Syncytial Virus Elicits Protective Immunity in BALB/c Mice. Biochem Biophys Res Commun, 2009. 381: 528-532 (corresponding author) 
6. Xie Can, He Jinsheng, Zhang Mei, Shao-Li Xue, Qiang Wu, Xiang-Dong Ding, Wei Song, Yuan Yuan, Dong-Liang Li, Xian-Xian Zheng, Yan-Yan Lu and Zhi Shang. Oral RSV DNA Vaccine expressing RSV F Protein Delivered by Attenuated Salmonella Typhimurium. Human Gene Therapy, 2007, 18(8): 746-752 (corresponding author)
  Awards&Honors
 

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